Shanghai Academy of Agricultural Sciences

Shanghai Zheye Biotechnology Limited Liability Company

Jianyu Liu

Yu Meng Li

Feng Zhou

Dan Zhang

Hui Calvin Yang

Haidong Harry Zhang

Hailong Yu

Zhen Xu

Lujun Zhang

Xiaodong Shang

Ning Jiang

Qiaozhen Li

Ruijuan Wang

Chunyan Song

Qi Tan

Meiyan Zhang

Haidong Zhang

Provided are a compound of formula (I), a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof, use thereof as a selective inhibitor for FGFR4 kinase and use thereof in manufacturing a medicament or pharmaceutical composition for treating diseases due to FGFR4 or FGF19. The compound disclosed by the invention has selective and significant inhibitory activities against FGFR4, and has wide application prospect in the field of tumor treatment. 

Compound for selectively inhibiting kinase and use thereof

A method for genetic transformation of edible mushrooms is provided relating to the technical field of genetic transformation of, enoki mushroom and shiitake. The disclosed method for genetic transformation ofincludes: inoculatingliquid mycelia into a foxtail-millet-grain culture medium, and pre-culturing them at 20-25&#xb0; C. untilmycelia grow on surfaces of foxtail millet grains. This method uses the foxtail millet grains as an attachment matrix, and during the pre-culturing and co-culturing, the culture substrate is shaken up every day. The method for genetic transformation of enoki mushroom or shiitake includes: inoculation of enoki mushroom mycelia or shiitake mycelia, activated culturing of, andinfecting a foxtail millet grain-enoki mushroom mycelium matrix or a foxtail millet grain-shiitake mycelium matrix.

Method for genetic transformation of edible mushrooms

Growing community of inventors

Shanghai, China

Jianyu Liu