Gilead Sciences, Inc.

Jianying Wang

Choung U Kim

Edward Doerffler

Zheng-Yu Yang

Maria Fardis

Gong-Xin He

Aesop Cho

William A Lee

John C Rohloff

Michael O Clarke

Gary Paul Cook

Xiaoning C Sheng

Xiaoqin Cheng

Kleem Chaudhary

Anthony Casarez

Hyungjung Pyun

Manoj C Desai

Richard L Mackman

Matthew A Williams

Hyung-Jung Pyun

Michael L Mitchell

Lianhong Xu

Kuei-Ying Lin

Sundaramoorthi Swaminathan

Hongtao Liu

Haolun Jin

Lijun Zhang

Xiaowu Chen

Richard Yu

Mark L Sparacino

Jiancun Zhang

Murty N Arimili

Gary P Cook

Xiaqin Cheng

The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Antiviral phosphinate compounds

The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound.

Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein:

Anti-proliferative compounds, compositions, and methods of use thereof

Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds

Growing community of inventors

Foster City, CA, United States of America

Jianying Wang