Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

Shanghai Hansoh Biomedical Co., Ltd.

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Changzhou Hansoh Pharmaceutical Co., Ltd.

Jianyan Xu

Weikang Tao

Ying Zhang

Guiyang Jiang

Lei Zhang

Lianshan Zhang

Ling L Zhang

Hua Ying

Yayuan Fu

Yali Wang

Dongbing Cui

Jiajian Liu

Ting Zhang

Ling Zhang

Jindong Liang

Bolei Qu

Dong Ma

Junzhuan Qiu

Ziyong Sun

Jiping Zha

Jingping Wei

Disclosed by the present invention are an anti-B7H3 antibody-exatecan analog conjugate, a preparation method therefor and an anti-tumor medicinal use thereof.

Anti-B7H3 antibody-exatecan analog conjugate and medicinal use thereof

Provided are an anti-c-Met antibody or an antigen binding fragment thereof, and an anti-c-Met antibody-cytotoxic drug conjugate, wherein the antibody or antigen binding fragment thereof is a chimeric antibody or a humanized antibody. Also provided are pharmaceutical compositions containing the humanized anti-c-Met antibody or antigen binding fragment thereof, the antibody-cytotoxic drug conjugate, or pharmaceutically acceptable salts or solvents thereof, that are used in the treatment of cancer.

Anti-c-Met antibody and anti-c-Met antibody-cytotoxic drug conjugate and pharmaceutical use thereof

The present invention relates to a new toxin and a method for preparing an intermediate thereof. In particular, the present invention relates to a new toxin and a method for preparating intermediates of Formula (III) and Formula (IV) thereof, and a preparation method for synthesizing what is shown in general formula (I). The method comprises subjecting a chiral compound shown in general formula (III) to a series of protecting group additions, protecting group removal and amidation so as to obtain a compound as shown in general formula (I). The present method has the advantages of mild reaction conditions, simple operation, high optical purity and high synthetic yield, and thus is suitable for large-scale production. 

Toxin and method for preparing intermediate thereof

Growing community of inventors

Shanghai, China

Jianyan Xu