Bionumerik Pharmaceuticals, Inc.

Jianyan Wang

Frederick H Hausheer

Harry Kochat

Ye Wu

Qiuli Huang

Xinghai Chen

Kesavaram Narkunan

Vincent Gerusz

A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with a silylated heterocyclic compound in a modified Minisci-type alkylation reaction to produce 7-substituted derivatives of camptothecin.

Process for making camptothecin derivatives

A process for synthesizing substantially enantiomerically pure L-amino acids, particularly L-&#x3b3;-methylene glutamic acid, and esters and salts thereof. The process includes the derivatization of (2S)-pyroglutamic acid, and the decyclization of the resulting derivative to form the desired end product.

Process for synthesizing L-&#x3b3;-methylene glutamic acid and analogs

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Helotes, TX, United States of America

Jianyan Wang