University of Utah Research Foundation

Jianxing Zhang

Glenn D Prestwich

Thomas P Kennedy

Narayanam Rao

Xiaoyu Xu

Xiayou Xu

Described herein are methods for treating inflammation in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue is substituted with a C-Cunsubstituted alkyl group or fluoroalkyl group.

Use of alkylated semi-synthetic glycosaminoglycosan ethers for the treatment of inflammation

Described herein are methods for treating a dental disorder in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary C-6 hydroxyl proton of at least one N-acetyl-glucosamine residue is substituted with a C-Cunsubstituted alkyl group or fluoroalkyl group.

Use of alkylated semi-synthetic glycosaminoglycosan ethers for the treatment of dental disorders

Described herein is the synthesis of alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as 'SAGEs.' The synthesis of sulfated alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including wound healing, drug delivery, and the treatment of a number of inflammatory diseases and skin disorders.

Alkylated semi synthetic glycosaminoglycosan ethers, and methods for making and using thereof

Described herein are alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as 'SAGEs.' The synthesis of sulfated and alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including use for ocular or ophthalmic treatment.

Growing community of inventors

Salt Lake City, UT, United States of America

Jianxing Zhang