Wyeth

American Home Products Corporation

Zealand Pharma A/s

Scientific-Atlanta, Inc.

Jianxin Ren

Panolil C Raveendranath

Silvio Iera

Joseph Zeldis

John R Potoski

Galina Vid

Anita Wai-Yin Chan

Lalitha Krishnan

Mousumi Ghosh

John Leo Considine

Karen Sutherland

Charles Chao Wu

Mahmoud Mirmehrabi

Subodh S Deshmukh

Maotang X Zhou

Asaf Ragim Alimardanov

Ting-Zhong Wang

Jason Brazzillo

Gary Paul Stack

Amedeo A Failli

Christoph Martin Dehnhardt

Annmarie Louise Sabb

Reinhardt Bernhard Baudy

Warren Chew

Sreenivasulu Megati

Ronald Stanley Michalak

Yanzhong Wu

Arkadiy Zinoviy Rubezhov

Deborah Ann Evrard

Robert Lewis Vogel

Ramesh Nallur

Peter Chan

Yanfang Li

Scott Mason Duncan

Sylvain Daigneault

Mahmut Levent

Charles Guinosso

Antonia Nikitenko

Jean Yi-ching Sze

Charles John Stanton, Iii

Yangzhong Wu

John Richard Potoski

Ben Cook

Karen Wiggins Sutherland

Charles C Wu

Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

Synthesis of pyrrolidine compounds

Processes for preparing sulfonamide trifluoroalkyl substituted alcohol compounds are provided. Desirably, the compounds are heterocyclic sulfonamide trifluoroalkyl substituted alcohol compounds or phenyl sulfonamide trifluoroalkyl substituted alcohol compounds.

Selective N-sulfonylation of 2-amino fluoro- and trifluoroalkyl substituted alcohols

Processes for preparing amino alcohols or salts thereof and sulfonamide substituted alcohol compounds are provided. Desirably, the sulfonamide substituted alcohol compounds are heterocyclic sulfonamide trifluoroalkyl-substituted alcohol compounds or phenyl sulfonamide trifluoroalkyl-substituted alcohol compounds.

Methods for preparing sulfonamide substituted alcohols and intermediates thereof

A process for making the compound of formula (I) wherein Ac represents acetate; X represents O or CH; Y represents C-Calkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF, OCF, OH, C-Calkyl, C-Calkoxy, C-Cthioalkyl, NH, N(C-Calkyl), NH(C-Calkyl), NC(O)&#x2014;(CCalkyl), and NO. In his process, a compound of formula (II) is reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).

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A process for making a compound of formula I and intermediate compounds thereof, wherein Ris CN, F or Cl; Ris H or Br; and Rand Rare each independently H or F. The compounds of formula I are useful in the treatment of chronic inflammatory diseases, such as rheumatoid arthritis.

Process for the synthesis of 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthonitrile

The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HTreceptors and modulating serotonin levels.

Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives

This invention provides a compound of Formula (I): wherein

Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines

The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula:

Aryloxy-alkyl-dialkylamines

The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are, independently, selected from H; C.sub.1 -C.sub.12 alkyl or C.sub.1 -C.sub.6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are independently selected from H, halogen, --NO.sub.2, alkyl, alkoxy, C.sub.1 -C.sub.6 perfluorinated alkyl, OH or the C.sub.1 -C.sub.4 esters or alkyl ethers thereof, --CN, --O--R.sup.1, --O--Ar, --S--R.sup.1, --S--Ar, --SO--R.sup.1, --SO--Ar, --SO.sub.2 --R.sup.1, --SO.sub.2 --Ar, --CO--R.sup.1, --CO--Ar, --CO.sub.2 --R.sup.1, or --CO.sub.2 --Ar; and Y is selected from a) the moiety: ##STR2## wherein R.sub.7 and R.sub.8 are independently selected from the group of H, C.sub.1 -C.sub.6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of --O--, --NH--, --N(C.sub.1 C.sub.4 alkyl)--, --N.dbd., and --S(O).sub.n --.

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Nanuet, NY, United States of America

Jianxin Ren