Nanjing Medical University

Simcere Pharmaceutical Co., Ltd.

Nanjing Hanwei Public Health Technology Co., Ltd.

Zhou, Jianwei

Jianwei Zhou

Aiping Li

Junjie Chen

Jin Xu

Chuanjun Shu

Yanlin Ren

Jiahua Cui

Dongyin Chen

Xuan Li

Yefei Huang

A prediction system for identifying key heterogeneous molecules that drive tumor metastasis including an input module, an analysis module, and an output module. The input module is configured to input a first quantitative analysis result of proteins and a second quantitative analysis result of proteins; the first quantitative analysis result of proteins is a collection of quantitative analysis results of various protein expression levels in tumor metastases of a target patient before drug intervention, and the second quantitative analysis result of proteins is a collection of quantitative analysis results of various protein expression levels in residual tumor metastases of the target patient after drug intervention. The analysis module includes a primary analysis submodule, a secondary analysis submodule, and a calculation and sorting submodule. The primary analysis submodule is used for preliminary screening analysis. The output module is used to output a sorted list of heterogeneous molecules.

Prediction system for identifying key heterogeneous molecules driving tumor metastasis

A compound as shown in formula I. Ris selected from the group consisting of &#x2014;OH, &#x2014;CH, &#x2014;CHCH, &#x2014;OCH, &#x2014;OCHCH; Ris selected from the group consisting of &#x2014;H, &#x2014;OH, &#x2014;CH, &#x2014;CHCH, &#x2014;CHCHCH, &#x2014;OCH, &#x2014;OCHCHCH; Ris selected from the group consisting of &#x2014;F, &#x2014;Cl, &#x2014;Br, &#x2014;I, &#x2014;CF; Ris selected from the group consisting of &#x2014;H, &#x2014;F, &#x2014;Cl, &#x2014;Br, &#x2014;I, &#x2014;CF; and Ris selected from the group consisting of &#x2014;H, &#x2014;CH, &#x2014;CHCH.

[object Object]

An anti-tumor polypeptide, having an amino acid sequence represented by FPGSDRF (SEQ ID NO: 15), X-FPGSDRF (SEQ ID NO: 16), FPGSDRF-Z (SEQ ID NO: 17), or X-FPGSDRF-Z (SEQ ID NO: 18) is disclosed. The various capital letters denote amino acids: F: phenylalanine; P: proline; G: glycine; D: aspartic acid; R: arginine; S is a phosphorylated serine residue, X and Z are an amino acid residue or an amino acid sequence, respectively, X is one selected from the group consisting of F, (R)(SEQ ID NO: 19), (R)-F (SEQ ID NO: 20), 6-aminocaproic acid, 6-aminocaproic acid-F, 6-aminocaproic acid-(R)(SEQ ID NO: 21), and 6-aminocaproic acid-(R)-F (SEQ ID NO: 22), Z is one selected from the group consisting of A, (G)-RGD (SEQ ID NO: 23), and A-(G)-RGD (SEQ ID NO: 24); and n is an integer greater than or equal to 0.

Anti-tumor polypeptides and method for preparing anti-tumor drugs comprisng the same

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Nanjing, China

Jianwei Zhou