Other

Shanghai Changzheng Hospital

Second Affiliated Hospital of Second Military Mediccal University, Shanghai

Jianru Xiao

Xiaopan Cai

Jun Wei Zhang

Dan Zhang

Hong Ding

Da Wang

Yiyun Cheng

Shungui Chen

Xinghai Yang

Haiyi Gong

Tielong Liu

Zhipeng Wu

Jian Jiao

Bowen Yuan

Siwang Hu

Wanwan Shen

Shaohui He

The present application relates to the technical field of medical instruments and provides an anti-loosening medical screw based on an organism osteogenesis function. The medical anti-loosening screw comprises a screw cap and a screw rod connected to the screw cap. The screw rod comprises a main rod and a thread spirally wound around the main rod. The cross section of the main rod is non-circular. The present medical anti-loosening screw based on an organism osteogenesis function can be applied to the medical fields such as orthopedics (spine, four limbs, pelvis, joints, etc.), maxillofacial surgery, odontology, and veterinarians and can be effectively prevented from loosening after operation after being implanted.

Medical anti-loosening screw based on organism osteogenesis function

A composition for gene therapy or transfection includes nucleic acid, natural polyphenol, and cationic molecules. There are several phenolic hydroxyl groups in the natural polyphenol, so as to eliminate free radicals, prevent cancer, fight inflammation, and provide antioxidants feature. Compared with the delivery of cationic molecules alone, the composition can significantly improve the transfection efficiency by about 60-70%, reduce the dose of effective transfection of cationic molecules by about 20 times, thereby reducing the toxicity of transfection and showing better organism compatibility. The composition of the present invention does not introduce other chemical reagents, does not require synthesis, has high biosafety, and can efficiently and safely deliver a plurality of nucleic acid molecules into cells. The composition can be used as a highly effective and low-toxicity nucleic acid drug in the treatment of gene-related diseases, and has good medicinal value.

Composition for gene therapy or transfection, and preparation method and use thereof

The invention relates to an assembled vertebral body used in a cervical reconstruction operation, comprising: an upper connecting element, an artificial vertebral body element and a lower connecting element, wherein the upper connecting element is disposed at an upper part of the artificial vertebral body element, the lower connecting element is disposed at an lower part of the artificial vertebral body element, and wherein the artificial vertebral body element is assembled with the upper connecting element and the lower connecting element, respectively. The invention has the advantages that the artificial vertebral body element is customized in accordance with the characteristics of patients and printed in 3D, and the length of the artificial vertebral body element can be precisely adjusted to adapt to the patient. Since the lower connecting element is standard part, the upper connecting element is standard part or non-standard part, and the artificial vertebral body element is non-standard part, in comparison to the traditional 3D printing which needs to be printed integrally, the adjustable assembled artificial vertebral body can reduce 3D printing materials and reduce the cost of 3D printing, thus reducing medical costs for the patient. The shape of the nested parts of the elements is a non-circular shape, which can resist rotation, so that no relative movement occurs among the three elements of the artificial vertebral body.

Assembled vertebral body

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Shanghai, China

Jianru Xiao