Grand Theravac Life Sciences (nanjing) Co., Ltd.

Jiangsu Theravac Bio-pharmaceutical Co., Ltd.

Jianqiang Li

Jun Ge

Tong Zhou

Xiaoxiao Chen

Hongying Huang

Yue Gu

Honglin Sun

Jiaojiao Sun

Sulin Ren

Ying Sun

Yue Chen

Xiaodong Wang

Xue Zhou

Jingfeng Huang

Meiju Wang

Xiaoqian Zhuang

Sean Xiaohan Du

Zhenxing Xu

Cuiling Song

Shiwei Wang

A pharmaceutical composition comprising: i) a herpes gE protein, an active fragment of the protein, a variant of the protein, or a mixture of at least two of them; ii) an immunostimulatory composition comprising a saponin and a CpG oligodeoxynucleotide, or consisting of an adjuvant comprising a saponin and a CpG oligodeoxynucleotide. Use of the pharmaceutical composition in the preparation of a medicament for preventing and/or treating a varicella-zoster virus infection and/or a varicella-zoster virus mediated disease. The pharmaceutical composition achieves an unexpected technical effect and can mediate a stronger immune response.

Pharmaceutical composition and use thereof

The present invention discloses a pharmaceutical preparation for treating hepatitis B, a preparation method and use thereof. The pharmaceutical preparation comprises a solution of hepatitis B surface antigen, further a solution of hepatitis B core antigen, and furthermore an oligodeoxynucleotide solution. The pharmaceutical preparation is free of saccharide, has a simple composition and a good antigen stability, without the adverse reactions caused by aluminum adjuvants, and shows good preservation effects in long-term stability experiments.

Pharmaceutical preparation for treating hepatitis b, preparation method therefor and use thereof

Disclosed is a composition comprising: i) HBsAg, a fragment thereof, a variant thereof, or the mixture of at least two of them, ii) HBcAg1-X, a fragment thereof, a variant of the antigen or the antigen fragment, or the mixture of at least two of them, wherein X is an integer of from 149 to 183, iii) CpG-ODN, 21 bases long, which is a phosphorothioate oligonucleotide and includes two or more copies of 5'-NTCGTT-3&#x2032; motifs. The use of the composition in the treatment of HBV-infection and HBV-induced diseases, and the therapy methods of HBV-infection and HBV-induced diseases are also disclosed.

Hepatitis B vaccine

Growing community of inventors

Nanjing, China

Jianqiang Li