General Electric Company

Insilico Medicine IP Limited

Shanghai Heartcare Medical Technology Co., Ltd.

Jianping Wu

Yong Liang Liu

Zhen Wang

Dong Liu

Yuanfeng Luo

Hong Qing Zhou

Lei Yang

Renwei Yuan

Liming Zhang

Howard Paul Weaver

Luoheng Qin

Yingna Wu

Guohui Wang

Yibo Gao

Jinxin Liu

Zongyu Xue

The disclosure provides for small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. The disclosure further provides methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.

Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof

Disclosed is a thrombectomy stent system, comprising a thrombectomy stent, wherein the thrombectomy stent is roll-shaped, and the cross section of the thrombectomy stent is of an open-ring structure. Disclosed is a thrombectomy device, comprising the thrombectomy stent, wherein the thrombectomy stent is provided with a developing element that can accurately display the expansion state of the thrombectomy stent during thrombectomy and the specific position of the thrombectomy stent so as to determine the situation of the thrombectomy stent being fused with a blood vessel. Disclosed is a thrombectomy device system, comprising the thrombectomy stent and a push rod, wherein a proximal end of the thrombectomy stent is connected to the push rod, and the proximal end of the thrombectomy stent or the push rod is connected to a catching member; and the catching member is configured to receive the thrombectomy stent. The catching member can effectively catch a thrombus that is detached during the thrombectomy.

Thrombectomy device system

A method for removing oxide materials from a crack of a metallic workpiece comprises: infiltrating an alkali solution into the crack in a pressurized atmosphere or an ultrasonic environment; applying an energy to the crack to react the oxide materials with the alkali solution and form a resultant material; and rinsing the resultant material with an acid solution to remove the resultant material from the crack. The method is easier to penetrate into the inside of the cracks, in particular suitable for cleaning narrow and deep cracks.

Method for removing oxide materials from a crack

A machining system for electromachining a workpiece that in one embodiment includes a machine tool, a cutting tool for performing the eletromachining, and a tool holding apparatus for conductively holding the cutting tool and coupled to the machine tool. The tool holding apparatus includes a holding element for holding the cutting tool and at least one solution releasing element. The solution releasing element is used to receive machining solution and release the machining solution onto a predetermined area of the cutting tool through at least one group of channels. Each group of channels includes at least two channels configured to respectively release the machining solution onto at least two adjacent sections in the predetermined area of the cutting tool.

Machining system and tool holding apparatus thereof

Growing community of inventors

Shanghai, China

Jianping Wu