Hoffmann-la Roche Inc.

Zhejiang Dade Pharmaceutical Group Co., Ltd.

Semiconductor Manufacturing International (shanghai) Corporation

Hangzhou Eyeskey Optical Instrument Co., Ltd.

F. Hoffmann-la Roche Ag

Jianping Wang

Chungen Liang

Hongying Yun

Kun Miao

Xiufang Zheng

Jianguo Wang

Song Yang

Bo Zhang

Xingchun Han

Lu Gao

Yongguang Wang

Min Jiang

Robert James Weikert

Hassan Javanbakht

Chengang Zhou

Zhanguo Wang

Weiping Shen

Jun Wu

Fei Wang

Xuefei Tan

Yongfu Liu

Feng Qian

Song Feng

Jinghua Ni

Song Pan

Jingang Wu

Hongmei Jin

The present invention provides novel compounds having the general formula (I) wherein Rto R, and m are as described herein, compositions including the compounds and methods of using the compounds.

Chromen-4-one derivatives for the treatment and prophylaxis of hepatitis B virus disease

The present invention relates to compounds of formula (I), 

Sulfonimidoylpurinone compounds and methods of treatment using the same

The present invention relates to compounds of formula (I),  wherein R, Rand Rare as described herein, and their prodrugs or pharmaceutically acceptable salts, enantiomers or diastereomers thereof, and compositions including the compounds and methods of using the compounds.

Sulfone compounds and derivatives for the treatment and prophylaxis of virus infection

7-substituted sulfonimidoylpurinone compounds for the treatment of virus infection

Sulfonimidoylpurinone compounds

7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection

Universal smartphone adapter

The invention provides novel compounds having the general formula: wherein R, R, R, R, Rand Rare as described herein, compositions including the compounds and methods of using the compounds.

Dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection

The invention provides novel compounds having the general formula:  wherein R, R, R, X and a are as described in the description and in the claims, as well as or pharmaceutically acceptable salts thereof. The invention also contains compositions including the compounds and methods of using the compounds.

Pyridazones and triazinones for treatment and prophylaxis of hepatitis B virus infection

Sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection

Disclosed are selective phosphodiesterase inhibitor compounds shown in formula (I) or (II) for treating Erectile Dysfunction, the pharmaceutically acceptable salts and configurational isomers thereof. In the formula, the substituents R, R, R, Rand Rare defined as in the specification. Also disclosed are methods for preparing same, and a medical composition comprising compounds of formula (I) or (II), and the use of these compounds for preparing a drug treating or preventing male Erectile Dysfunction.

Pyrazolopyrimidinone compound and imidazo triazone compound for treating erectile dysfunction

Various embodiments provide semiconductor structures and fabrication methods. In an exemplary method, a semiconductor substrate can contain a shallow trench isolation (STI) structure that includes a fuse region. A protective layer can be provided on the high-K dielectric layer, which is provided on the semiconductor substrate. A portion of each of the protective layer and the high-K dielectric layer can be removed from the fuse region to expose the STI structure. A fuse layer can be formed on the exposed surface of the STI structure. A portion of the fuse layer, the remaining portion of the protective layer, and a remaining portion of the high-K dielectric layer outside of the fuse region can be removed from the semiconductor substrate to form a fuse structure.

Semiconductor structure and fabrication method

The invention disclosed a total synthesis process of novel ethoxy combretastatins and their prodrugs. Combretastatins are chemically modified by ethoxy substituted on the 4'-position of their B aryl ring and are converted to be their soluble prodrugs of phosphate or their inner salt of phosphorylcholine by modifying the hydroxyl on the 3&#x2032;-position of their B aryl ring. Similarly, 3&#x2032;-amino combretastatin is 4&#x2032;-ethoxy chemically modified and further side chain of amino acid can be introduced to the amino to form soluble prodrug of amino acidamide. The structure of the said compound is showed as formula (I). Ethoxy combretastatins possess potent tubulin polymerization inhibitory activity and can be used for the treatment of inhibiting tumor or neovascular. 

Preparation and the use of ethoxy combretastatins and their prodrugs

Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Ris alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.

Fluoroalkoxycombretastatin derivatives, method for producing the same and use thereof

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Shanghai, China

Jianping Wang