L'oreal

2y-chem, Ltd.

Jianping Guo

Herve Richard

Lei Zhang

Hervé Richard

Wensheng Tang

Patricio Guerreiro

Xungui He

Jinzhu Xu

Yanling Wang

Xuezhang Wang

Xingzhong Zhang

The process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds and the process for preparing siloxane compounds containing 2-hydroxyphenyl benzotriazole function are disclosed.

Process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds; use of the said compounds obtained via the process in the synthesis of siloxane compounds containing a 2-hydroxyphenylbenzotriazole function

A process for preparing a siloxane compound comprising a 2-hydroxyphenyl benzotriazole function which comprises at least one step in which a reaction for hydrosilylation of a compound 2-hydroxyphenyl benzotriazole comprising a substituent having a terminal double bond with a siloxane compound comprising an SiH function is carried out in the presence of a catalyst and of at least one volatile organic solvent corresponding to one of formula (VII) or (VIII). in which Rand R, which may be identical or different, represent a linear or branched C-Calkyl radical, with the proviso that the sum of the carbons of Rand Ris less than or equal to 6; y is and integer between 1 and 3; Rwhich may be identical or different, are linear or branched C-Calkyl radicals, with the proviso that the sum of the carbons of Ris less than or equal to 6 is disclosed. 

Process for preparing 2-hydroxyphenyl benzotriazole siloxane compounds

The chiral compound S-5-substituted-N-2'-(thienyl-2-yl-)ethyl-tetralin-2-amine or its chiral acid salts and preparation method thereof are disclosed, and the method for preparing Rotigotine by using the chiral compound is also disclosed. Racemic 5-substituted-N-2&#x2032;-(thien-2-yl-)ethyl-tetralin-2-amine (compound 1) is resolved by using a conventional chiral acid to obtain an optically pure chiral acid salt of S-5-substituted-N-2&#x2032;-(thien-2-yl-)ethyl-tetralin-2-amine, which is then dissociated to obtain S-5-substituted-N-2&#x2032;-(thien-2-yl-)ethyl-tetralin-2-amine (compound 2). The compound 2 or chiral acid salt thereof is alkylated and deprotected to produce rotigotine (compound 5). 

S-5-substituent-N-2'-(thiophene-2-yl)ethyl-tetralin-2-amine or chiral acid salts thereof and use for preparing Rotigotine

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Jiangxi, China

Jianping Guo