Hoffmann-La Roche Inc.

Takeda Pharmaceutical Company Limited

F. Hoffmann-La Roche Ag

Jianping Cai

Robert Alan Goodnow, Jr

Kin-Chun Thomas Luk

Xin-Jie Chu

Peter Michael Wovkulich

Steven Gregory Mischke

Kang Le

Shaoqing Chen

Bernd Kuhn

Werner Neidhart

Yi Heng Chen

Daniel Hunziker

Alexander Mayweg

Paul Gillespie

Stefan Scheiblich

Fariborz Firooznia

Kurt E Amrein

Nader Fotouhi

Allen John Lovey

Konrad Honold

Binh Vu

Georg Tiefenthaler

John Frederick Boylan

Nikolaos Dimoudis

Kevin Richard Guertin

Christophe Michoud

Hongju Li

David Joseph Bartkovitz

Lida Qi

Chunlin Zhao

Hongmao Sun

Adrian Wai-Hing

Hilke Sudergat

Oliver Tonn

Binh Thanh Vu

There are provided compounds of the formula or the pharmaceutically acceptable salts thereof, wherein X, Y, Z, V, V, R, R, R, Rand Rare herein described. These compounds are useful as anticancer agents.

Chiral cis-imidazolines

The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.

Thiazolyl-benzimidazoles

The present invention provides PLK1 inhibitor compounds of formula I: useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

Halo-substituted pyrimidodiazepines

Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein Rto Rhave the significances given in the description and claims can be used in the form of pharmaceutical compositions.

Indazolone derivatives useful as 11b-HSD1 inhibitors

There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.

Substituted N-acyl-2-aminothiazoles

Combinatorial libraries that contains various different 4, 5 fused 3-substituted-2-pyrrolocarboxylic acids for screening pharmacological activity and methods of synthesizing said libraries.

Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid

Compounds of formula I are described. These compounds are protein kinase inhibitors, in particular they inhibit the src family tyrosine kinases. Thus, these compounds are useful for the treatment of diseases mediated by src tyrosine kinases, including cell proliferative disorders such as cancer. Also described are methods of making and using compounds of formula I as well as pharmaceutical compositions containing these compounds.

Amino-substituted dihydropyrimido[4,5-D]pyrimidinone derivatives

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Jianping Cai