Ascentage Pharma (Suzhou) Co., Ltd.

Ascentage Pharma Group Corp Limited

Guangzhou Healthquest Pharma Co., Ltd.

Ascentage Pharma Goup Corp Limited

Ascentage Pharma Co., Ltd.

Jianpeng Feng

Jianfeng Wen

Ming Guo

Tianzhu Wu

Huirong Lu

Jing Zhang

Yanqiong Lin

Ming Jin

Weidong Li

Shangjun Teng

Qianlei Cao

The present invention provides crystalline forms or amorphous forms of N-(phenylsulfonyl) benzoamide compound or its salts or solvates used as a Bcl-2 inhibitor, and the preparation method and the application thereof.

Crystalline forms or amorphous forms of N-(phenyl sulfonyl) benzamide compounds or its salts or solvates

Disclosed herein are a process for preparing alkynyl-containing compound and intermediate thereof. In particular, the present invention discloses a process for preparing a compound of formula 6 as shown in below and a pharmaceutical composition comprising a compound of formula 6 for treating cancer,

Process for preparing alkynyl-containing compound and intermediate thereof

Disclosed is a method for preparing 2-indolinospirone compound and intermediate thereof, specifically disclosed is a method for preparing a compound of formula 5. The method is relatively simple and has high stereoselectivity and yield.

Method for preparing 2-indolinospirone compound and intermediate thereof

The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.

Process for preparing sulfonamide compounds

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Suzhou, China

Jianpeng Feng