Chinese Academy of Medical Sciences

Jianpeng Du

Lei Zhang

Xin Wang

Kai Cui

Yuanyuan Cui

Jiangang Liu

Peili Wang

Dazhuo Shi

Zhengcai Zhang

Fuhai Zhao

Dawu Zhang

Disclosed is a stent with a drug coating for preventing and treating restenosis, comprising a stent and a drug coating covering the surface of the stent. The active ingredients in the drug coating are guaiane sesquiterpene compounds P1, P2 and P3. P1 is Zedoalactone B, P2 is a stereoisomer of P1, and P3 is Zedoarondiol. Compared with an existing sirolimus eluting stent, the present drug eluting stent can inhibit the intimal hyperplasia and the inflammatory reactions of vascular walls, and promote the endothelialization of blood vessels after the stent is implanted, and thus can prevent the long-term thrombotic complications; and has the advantages of small dosage, low cost, and no toxic side effect.

Scaffold with drug coating for treating restenosis and preparation method thereof

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Beijing, China

Jianpeng Du