Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd.

Guangdong Cs-Lewwin Drug Research Co., Ltd.

Gree Electric Appliances, Inc. of Zhuhai

Shenzhen Sdgi Optical Network Technologies Co., Ltd.

Jianmin Guo

Wei Yang

Xingshu Li

Xinzi Chen

Shiqiang Zhang

Huachao Jiao

Jie Wei

The present invention discloses a method of treating tumor using a novel pyrimidine derivative. It is demonstrated through the tests on anti-tumor activity at the cellular level (tumor cells expressed with c-Met) that, through the introduction of a chiral structure in the molecule, the introduction of an isotope of hydrogen (deuterium) at the sites that are prone to metabolism in the molecule, and the introduction of atoms or groups such as sulfur, selenium and sulfoxide in the molecule, the compounds of the invention have excellent anti-tumor activities, and the stabilities of the anti-tumor compounds are significantly improved.

Pyrimidine derivative and preparation process and use thereof

The present invention discloses a novel pyrimidine derivative and a preparation process thereof and a use thereof in anti-tumor drugs. It is demonstrated through the tests on anti-tumor activity at the cellular level (tumor cells expressed with c-Met) that, through the introduction of a chiral structure in the molecule, the introduction of an isotope of hydrogen (deuterium) at the sites that are prone to metabolism in the molecule, and the introduction of atoms or groups such as sulfur, selenium and sulfoxide in the molecule, the compounds of the invention have excellent anti-tumor activities, and the stabilities of the anti-tumor compounds are significantly improved.

The present invention discloses a pyrimidine derivative containing one deuterium atom, a preparation process thereof and a use thereof. It is demonstrated through in vivo and in vitro animal experiments that the antitumor activity of the pyrimidine derivative containing one deuterium atom provided in the disclosure is significantly superior to that of the positive drug Tepotinib, and the preparation process is simple and low in cost.

Pyrimidine derivative containing one deuterium atom and preparation process and use thereof

Provided are a control method and apparatus for increasing the amount of a circulating refrigerant, and an air conditioner. The control method includes: when a refrigerating capacity need is equivalent to a heating capacity need in the operation of an air-conditioning system, determining whether the discharge temperature of a compressor is greater than a preset safety alert value; if the discharge temperature of the compressor is greater than the safety alert value, adjusting the frequency of a fan of an outdoor heat exchanger; and when the discharge temperature of the compressor is not greater than the safety alert value, controlling to stop the adjustment of the frequency of the fan, and maintaining the air-conditioning system to operate at the adjusted current frequency of the fan.

Control method and device for increasing amount of circulating refrigerant and air conditioner

An on-site hot-melt quick connector for optical fibers comprises a plug housing, a ferrule, an optical fiber telescopic protective tube, a tail end cover, a pressure welding protective tail handle and a compression ring. A front baffle ring is mounted in the plug housing and a rear baffle ring is mounted in the tail end cover. The ferrule and the optical fiber telescopic protective tube are positioned between the front baffle ring and the rear baffle ring and can move in the axial direction. As the quick connector for optical fibers of the invention has a definite space for movement in the axial direction, the optical fibers themselves can move along with the plugging action during butting, avoiding the bending of the optical fibers caused as they are unable to move, thus guaranteeing the transmission quality of the optical signals. The service life of the quick connector is also guaranteed.

Growing community of inventors

Guangdong, China

Jianmin Guo