University of Oklahoma

Jianlan You

Robert H Cichewicz

Lin Du

Saikat Haldar

Allison O Mattes

Shikha Srivastava

Cyclic depsipeptide-class molecules, referred to herein as persephacins (including analogs thereof), having similarities to aureobasidin A, are described. The persephacins have antimicrobial activity, such as antifungal activity against a diverse range of clinically-relevant fungal pathogens, antiprotozoan parasite activity, and antibacterial activity, and can be used for example in treatments of difficult-to-treat ocular fungal infections at lower concentrations than natamycin. The active compounds may be combined with a secondary compound in a composition.

Growing community of inventors

Norman, OK, United States of America

Jianlan You