Novartis Ag

Jianhua Wang

Zhongbo Fei

Huanqing Jia

Hao Zhang

Wei Zhang

Zhongcheng Min

Quanbing Wu

Huangchao Yu

Hui Wang

Yinbo Wan

Gang Lu

Xiaohui Lin

Wei Li

The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention, said manufacture including the manufacture and use of a compound of the formula VI; wherein Ris a secondary amino protecting group and Ris unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted aryl.

Manufacture of compounds and compositions for inhibiting the activity of SHP2

The invention relates to a method for the manufacture of a compound of Formula I as mentioned above, or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein A, LG, n and m are as defined in the Summary of the Invention.

Process of manufacture of a compound for inhibiting the activity of SHP2, as well as products resulting from acid addition

The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.

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Changshu, China

Jianhua Wang