Nanjing Redsun Biochemistry Co., Ltd

Nanjing Carephar Shenghui Pharmaceutical Co., Ltd.

Jiangsu Carephar Pharmaceutical Co., Ltd.

Jiangsu Carefree Pharmaceutical Co., Ltd

Jianhua Jiang

Tao Chen

Chaoran Luo

Yi Xue

Wenkui Wang

Yinlin Qin

Mei Su

Fujun Wang

Xinchun Chen

Dianhai Zhou

Qiu Jin

Ruikuan Yue

Honglong Chen

Shousheng Yan

Xianzhi Wu

Disclosed is a method for preparing 2,2'-dipyridine and derivatives thereof. The method includes: using pyridine represented by formula I or a derivative thereof as a raw material to generate 2,2&#x2032;-dipyridine represented by formula II by performing dehydrogenative coupling under the action of a supported catalyst in the presence of additives, where R is H, C-Calkyl, Cl, or Br. The method of the present invention features wide adaptability to raw materials, high atomic utilization rate, high catalyst activity, long service life, and fewer by-products.

Method for preparing 2,2'-dipyridine and derivatives thereof

The present invention relates to a new pyrrole sulfonyl derivative, and a preparation method and medical use thereof. In particular, the present invention relates to a pyrrole sulfonyl derivative as represented by general formula (I), a preparation method thereof, a pharmaceutical composition comprising the derivative, and a use thereof as a therapeutic agent, in particular as a gastric acid secretion inhibitor and as potassium-competitive acid blockers (P-CABs), wherein each substituent group of general formula (I) is the same as that defined in the description.

Pyrrole sulfonyl derivative, preparation method and medical use thereof

A method for preparing 1,1'-ethylene-2,2&#x2032;-bipyridinium dichloride includes mixing an aqueous diquat dibromide solution with hydrochloric acid, adding dropwise to a mixture of an organic solvent, a bromine absorbent, and an oxidant, and reacting to produce 1,1&#x2032;-ethylene-2,2&#x2032;-bipyridinium dichloride.

Method for preparing 1,1'-ethylene-2,2&#x2032;-bipyridinium dichloride

The invention relates to a 4-substituted pyrrolo[2,3-d]pyrimidine compound and the use thereof in preparing medications for treating JAK-targeted diseases such as rheumatoid, immune system diseases, and tumor. The 4-substituted pyrrolo[2,3-d]pyrimidine compound of the invention is as shown in chemical formula I.  The activity experimental results of the invention show that the new compound has obvious effect and activity in inhibition of Janus kinases, JAK-STAT, cell proliferation of human lymphocytoma, and rheumatoid arthritis.

4-substituted pyrrolo[2,3-d]pyrimidine compound and use thereof

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Nanjing, China

Jianhua Jiang