Ardelyx, Inc.

Jianhua Chao

Rakesh K Jain

Jason Gustaf Lewis

Helene Baribault

Jeremy Caldwell

Lily Hu

The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L, A, X, X, R, R, and Rare described herein.

Hormone receptor modulators for treating metabolic conditions and disorders

The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L, A, X, X, Y, Y, Y, Y, R, R, and Rare described herein.

Hormone receptor modulators for treating metabolic mutagenic and fibrotic conditions and disorders

The disclosure relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L, L, A, B, R, R, R, and Rare described herein.

Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators

The disclosure relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L, L, A, B, R, R, R, and Rare described herein. 

The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): (I), wherein L, A, X, X, R, R, and Rare described herein. 

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Fremont, CA, United States of America

Jianhua Chao