University of Michigan

Jiangyong Chen

Shaomeng Wang

Dongguang Qin

Shanghai Yu

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

Indole inhibitors of MDM2 and the uses thereof

This invention relates to compositions comprising co-crystals of (&#x2212;)-gossypol with a Ccarboxylic acid or Csulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (&#x2212;)-gossypol with a Ccarboxylic acid or Csulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.

Growing community of inventors

Ann Arbor, MI, United States of America

Jiangyong Chen