Teledyne Scientific and Imaging, LLC

Jiangying Zhou

Warren M Grill

Mario Aguilar

Stephen Simons

Aaron B Hawkins

Mark A Peot

Dennis Turner

A flat optogenetic cuff interface (FOCI) is configured for functional optical stimulation of axons in a single fascicle of a peripheral nerve bundle in which the axons have been genetically modified to express light sensitive proteins for excitation or inhibition of the nerves. The FOCI is configured to gradually reshape the single fascicle to a final height between 0.2 mm and 0.5 mm by reorganizing the individual axons within the fascicle without reshaping (and damaging) the individual axons. The FOCI facilitates stimulation of axons over the entire cross-section of the reshaped fascicle within the power limitations for pulsed laser energy. An electrical interface may be included to sense nerve activity of either the stimulated axons to provide closed-loop feedback to control the optical sources or stimulated axons of a different modality to record the response. The FOCI may be used as an interface for prosthetic devices to restore lost sensory or motor function, to augment human sensor or motor performance or to modulate autonomic functions.

Flat optogenetic cuff interface (FOCI) for a single nerve fascicle of the peripheral nervous system

A computer vision system provides a universal scene descriptor (USD) framework and methodology for using the USD framework to extract multi-level semantic metadata from scenes. The computer vision system adopts the human vision system principles of saliency, hierarchical feature extraction and hierarchical classification to systematically extract scene information at multiple semantic levels.

Biologically-inspired metadata extraction (BIME) of visual data using a multi-level universal scene descriptor (USD)

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Durham, NC, United States of America

Jiangying Zhou