Yangtze River Pharmaceutical Group Co., Ltd.

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

Shanghai Jemincare Pharmaceuticals Co., Ltd.

Jiangxi Jemincare Group Co., Ltd.

Jiangwei Wang

Yang Liu

Hui Li

Qing Shan Zhang

Qiong Zhang

Haibing Guo

Jianbiao Peng

Shuchun Guo

Yingtao Liu

Yonggang Chen

Baoxin Xi

Wangbin Sun

Shan Yao

Zhangping Kang

Yan Ye

A compound represented by formula (I), an optical isomer thereof and a pharmaceutically acceptable salt thereof, as well as an application of said compound as an FXIa inhibitor. 

Tricyclic compound, preparation method therefor and use thereof

The present disclosure relates to pyridinamine-substituted heterotricyclo compounds, a preparation method thereof, and a use thereof in medicines. Specifically, a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, a preparation method and a use thereof are disclosed, wherein the groups in the formula (I) are as defined in the Description and claims. 

Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof

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Shanghai, China

Jiangwei Wang