Shanghai Origincell Biological Cryo Equipment Co., Ltd.

Shanghai Origincell Medical Technology Co., Ltd.

Jianguo Qu

Jianxin Wang

Chen Luo

Jun Gu

Lingling Liu

Sheng Qiao

Huoming Qiao

Zhikang Liu

Yunxin Cao

An automated storage and retrieval device for a biological sample is provided. The automated storage and retrieval device includes an upper cabin and a liquid nitrogen storage tank, where the upper cabin is communicated with the liquid nitrogen storage tank through a storage and retrieval channel; the upper cabin is provided therein with an operation area; the operation area is provided with a rack gripping mechanism, a rack barcode scanning mechanism, a cryotube suction mechanism, and a cryotube barcode scanning mechanism, and is configured to retrieve and store samples from the liquid nitrogen storage tank in the upper cabin through the storage and retrieval channel; and the upper cabin is provided with a pressure relief member for automatically discharging a pressure of the upper cabin.

Automated storage and retrieval device for biological sample

A sample cooling and storage mechanism includes a refrigeration device and a gradient cooling device. The refrigeration device is configured to perform temperature-controlled refrigeration on storage vials. The gradient cooling device is configured to perform programmed gradient cooling on the storage vials. The refrigeration device includes at least one refrigeration zone. A nitrogen spraying component, a heating component and a storage vial rack are provided in the refrigeration zone. The nitrogen spraying component is configured to spray nitrogen in the refrigeration zone. The heating component heats the interior of the refrigeration zone. The sample cooling and storage mechanism achieves a gradient cooling function for biological samples through the gradient cooling device, thereby preventing damage to the biological samples caused by rapid cooling. In addition, the sample cooling and storage mechanism achieves a temperature-controlled refrigeration function for the biological samples through the refrigeration device.

Sample cooling and storage mechanism

A lifting basket, a lifting basket guiding mechanism and a lifting basket-type sample cryogenic storage device are provided. The guiding mechanism includes a storage member, an auxiliary guiding member and a driving member. The storage member is placed into a liquid nitrogen tank, provided with an opening at an upper end and sleeved onto an exterior of the lifting basket for restricting removal of a cryogenic vial storage member or a cryogenic vial stored inside the lifting basket. The auxiliary guiding member is arranged above the storage member and slidably connected to the storage member, and the auxiliary guiding member is sleeved onto the exterior of the lifting basket and is in contact with the lifting basket to perform relative sliding motion through a guiding structure. The auxiliary guiding member performs vertical motion relative to a storage frame and the lifting basket under the control of the driving member.

Lifting basket, lifting basket guiding mechanism and lifting basket-type sample cryogenic storage device

An extraction operation room is provided. The extraction operation room is provided with a multi-stage Z-direction extraction arm and an X-direction pushing system. Movement on a multi-distance road section in a Z-axis direction is realized by using the multi-stage Z-direction extraction arm, such that the movement of an extraction member on the multi-distance road section in the Z-axis direction is realized, thereby greatly increasing the depth or length of the movement in a Z axis. The corresponding X-direction pushing system is provided, and the X-direction pushing system realizes the movement of a tank cover of a sample storage tank or a storage box in an X-axis direction. An operation space is given when the movement in the Z-axis direction and the X-axis direction are implemented, and meanwhile, the extraction structure is reasonable in design, small in occupied space, relatively low in cost, and convenient and intelligent to operate.

Extraction operation room and intelligent sample access system

A spirally ascending/descending cryogenic storage apparatus, comprising a cryogenic storage tank, the temperature in the cryogenic storage tank being continuously maintained at a certain deep cryogenic range. A driving component and a rotating storage rack are provided within the cryogenic storage tank. Multiple shelf boxes can be stored in the circumferential direction of the rotating storage rack. The driving component can drive the rotating storage rack to spirally ascent or spirally descent in the cryogenic storage tank. An access opening is provided on the cryogenic storage tank. The multiple shelf boxes can rotate to a position corresponding to the access opening with the movement of the rotating storage rack. The cryogenic storage tank is a liquid nitrogen tank. Liquid nitrogen is provided at the bottom part within the liquid nitrogen tank.

Spirally ascending/descending cryogenic storage apparatus

A liquid nitrogen tank includes a tank, a storage rack and a drive component. The tank includes a tank cover, a tank body, a vacuum cavity layer and a heat-insulating cavity layer. The tank cover is disposed to cover on the tank body. An access door is provided on the tank body. A storage cavity is provided in the tank body. The heat-insulating cavity layer is provided on a periphery of the storage cavity. The vacuum cavity layer is provided on a periphery of the heat-insulating cavity layer. The storage rack is provided in the storage cavity. A plurality of cryopreservation tube racks are stored in the storage rack. The drive component can drive the storage rack to rotate and move up and down in the storage cavity, and can drive the plurality of cryopreservation tube racks to move to a position corresponding to the access door.

Liquid nitrogen tank

A tube-array-type liquid nitrogen container includes a container body having a mouth; a tube array component received in the container body; and a top cap sealing the mouth from above. The top cap is rotatable in the mouth. The tube array component is composed of a plurality of holding tubes. The holding tube is opened at one end thereof, wherein the opening thereof faces the top cap. The top cap has at least one tube access passing therethrough. Each tube access is atop covered by a tube access cover. The tube-array-type liquid nitrogen container uses a tube-array component composed of the a plurality of holding tubes to store the freezing tubes, and is cooperated with the rotatable top cap and an external robotic arm, thereby improving space utilization and thermal insulation, effectively ensuring safety of the freezing tubes, and facilitating automatic storage of freezing tubes.

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Shanghai, China

Jianguo Qu