Chengdu Easton Biopharmaceuticals Co., Ltd

Chengdu Organic Chemicals Co., Ltd., Cas

Jianguo Li

Haitao Yang

Qing Dong

Yang Liu

Ying Wang

Guodong Cen

Long Huang

Yongzhe Xiang

Hua Zhang

Gongying Wang

Jie Yao

Shaoying Liu

Xiangui Yang

Ziqing Wang

Qiangqiang Liu

Jianjing Jia

Provided a complex of formula is [3-((1S, 3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3'-methyl-2&#x2032;-(pentanoyl {2&#x2033;-(tetrazol-5-ylate) biphenyl-4&#x2032;-ylmethyl}amino) butyrate].XCa.YNa.ZHO, wherein X=1-3, Y=12-16, Z=9-18, and 2X+Y=18, and represented by formula (I). Also disclosed are the method of preparing the complex and the method of treating chronic heart disease using a medicament comprising the complex. 

Complex of angiotensin receptor antagonist and neutral endopeptidase inhibitor

A preparing method of an aliphatic polycarbonate is provided to synthesize oligomer monomers by a transesterification reaction of carbonic acid dialkyl esters and aliphatic diols with accelerants in an atmosphere of a protective gas, and generate an aliphatic polycarbonate polymer by a polycondensation reaction of the oligomer monomers in a condition of high temperature and low pressure. According to the disclosure, environmentally friendly compounds with low boiling points and low costs are utilized as the accelerants to substitute the enzyme or acid-base catalysts to prepare aliphatic polycarbonate polymers in the prior art, and the cost is reduced; meanwhile, in the process of generating the aliphatic polycarbonate polymers, the accelerants can be removed from the reaction system along with the pressure reduced in the reaction system. The synthesis system is simple; moreover, the aliphatic polycarbonate obtained by the preparing method provided by the disclosure has merits such as superior colors.

Preparing method of aliphatic polycarbonate

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Chengdu, China

Jianguo Li