Ethicon, Gmbh

Jianguo Jack Zhou

Sasa Andjelic

Jianxin Guo

Gerard H Llanos

Sai Veruva

Joseph Vliet

Dennis D Jamiolkowski

Modesto Erneta

Krasimira Hristov

James A Matrunich

Benjamin D Fitz

Kenneth Michael Keilman

G Gavin Chen

Gaoyuan Gavin Chen

Howard Scalzo

Glenn R Cook

Jerome A Fischer

Michel Gensini

Joseph Richard Vliet, Jr

John Collier

The present invention is directed to an absorbable hemostatic nonwoven patch that utilizes a biocompatible substrate comprised of melt-blown microfibers as webbed sheets that are layered and bonded/entangled in descending density and ascending porosity; with the substrate having a high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ability for laparoscopic use or trocar deployment, ultimately for functional use as a highly effective hemostat in addressing problematic bleeding during both open and minimally invasive surgical procedures.

Melt blown dressing with gradient density

A spinneret for extruding fibers includes a plate having a proximal surface and a distal surface. The spinneret includes a plurality of holes formed in the plate that extend between the proximal surface and the distal surface of the plate. The holes are spaced from one another, and each hole has a distal end that extends along a central axis. The spinneret has a plurality of contoured entrance zones formed in the proximal surface of the plate, whereby each contoured entrance zone is associated with one of the holes. Each contoured entrance zone extends distally from the proximal surface of the plate to a proximal end of the hole associated therewith. Each contoured entrance zone has substantially no planar or flat surfaces normal to the direction of the central axis of the distal end of the hole associated therewith.

Spinnerets, breaker plates and die bodies having contoured surfaces with no flat surfaces between adjacent holes

The present invention is directed to an absorbable hemostatic patch that utilizes a biocompatible fibrous, fabric substrate that is melt-blown and napped or loosened at the surface, with the substrate having a low-profile, high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ultimately effective for use as a hemostat in situations of problematic bleeding.

Napped coated wound dressing

An absorbable hemostatic nonwoven patch utilizes a biocompatible substrate comprised of melt-blown microfibers as webbed sheets that are layered and bonded/entangled in descending density and ascending porosity; the substrate having a high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ability for laparoscopic use or trocar deployment, ultimately for functional use as a highly effective hemostat in addressing problematic bleeding during both open and minimally invasive surgical procedures.

Novel bioabsorbable, nasal spreader graft implant devices are disclosed. The devices are useful in rhinoplasty and nasal reconstruction surgical procedures, as well as other surgical procedures. The devices have biodegradable core plates and biodegradable spreader plates or tissue ingrowth plates. The plates may have tissue ingrowth properties.

Bioabsorbable multilayer nasal valve spreader graft

A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.

Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates

Copolymers exhibiting the following combinations of properties, including without limitation, &#x3b5;-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25&#xb0; C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein.

Copolymers of E-caprolactone and glycolide for melt blown nonwoven applications

Copolymers of epsilon-caprolactone and glycolide for melt blown nonwoven applications

We have discovered a surgical filament suitable for use as a suture or ligature that comprises a multifilament core having a plurality of filaments that are oriented having an external surface and internal interstices; and an outer coating that bonded to the external surface of the core but does not penetrate into the internal interstices of the core and a process for making these sutures.

Growing community of inventors

Bethlehem, PA, United States of America

Jianguo Jack Zhou