Zhejiang Huahai Pharmaceutical Co., Ltd.

Shanghai Syncores Technologies Inc. Ltd.

Shanghai Aobo Pharmtech, Inc., Ltd.

Jianguo An

Luning Huang

Hong Gu

Anping Tao

Xiaowen Guo

Kaiqiang Shi

Chen Liu

Yang Liu

Hao Lu

Jicheng Zhang

Jintao Yang

Kai Yin

Haisheng Fan

Xing Li

Huaxiang Ye

Yukun Liang

Xiang Ji

Yipeng Zhan

Yikai Zhang

Junzheng Huang

Hu Su

Yafei Jiang

Yuanhai Gao

Fenghao Liu

Kang He

A method for preparing lurasidone hydrochloride by reacting lurasidone free alkali reacts with hydrochloric acid in a mixed solvent of an alcoholic solvent and an alkyl halide solvent.

Method for preparing lurasidone hydrochloride

The present application relates to a method (I) for preparing a brivaracetam intermediate, comprising the steps of dissolving the compound represented by B-P and 1S,2S-diphenylethylenediamine in a solvent for resolution, crystallizing, filtering, and recrystallizing to obtain the compound represented by B-Q, which is then converted to the brivaracetam intermediate represented by B-R. This method can effectively resolve the compound represented by B-P. The present application also provides a method for preparing brivaracetam using the compound represented by B-R. The method can separate the effective components only through simple steps such as extraction, washing, drying, and concentration without requiring use of chiral chromatography column to separate isomers in the preparation process, and thus the separation process is simple, greatly reducing the production cost of brivaracetam.

Method for preparing brivaracetam and intermediate thereof

The present application relates to a method for citalopram intermediate citalopram diol. The method comprises: first mixing two Grignard reagents required for a reaction; then mixing the mixed Grignard reagents with a raw material 5-cyanophthalide in a temperature-controllable micromixer to obtain a reaction solution; then subjecting the reaction solution to the reaction by means of a reactor to obtain a citalopram diol reaction solution; and then performing operations such as quenching, concentration, extraction, acidification, and crystallization to obtain a qualified product. The citalopram diol provided in the present invention has good selectivity, high yield, high safety, safety and reliability, and little sewage discharge, and is suitable for industrial production.

Method for continuously preparing citalopram diol

The present invention relates to a method for preparing an intermediate (Formula IV) of sodium elagolix. The intermediate is prepared by the following route. The method has advantages of simple and safe operation, high yield, less environmental pollution, good economic effect and suitability for industrial production, wherein R represents C1-C4 substituted or unsubstituted benzyl or allyl. 

Method for preparing elagolix intermediate and composition thereof

Growing community of inventors

Shanghai, China

Jianguo An