National Institute of Biological Sciences, Beijing

Jianguang Han

Xiaodong Wang

Zhiyuan Zhang

Shaoqiang Huang

Li Li

Zhaolan Zhang

Xian Jiang

Lei Liu

Bo Yan

Huayi Wang

Zhi Huang

Weiye Cao

The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

Apoptosis inhibitors

The invention provides compounds that inhibit human MLKL, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

MLKL inhibitors

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Beijing, China

Jianguang Han