Chinese Academy of Sciences

Chinese Academy of Medical Sciences

Hankang Biochemical & Pharmaceutical Co., Ltd

Jiangong Shi

Jianjun Zhang

Yafang Wang

Yongchun Yang

Yan Li

Jing Wang

Min Li

Dan Zhang

Sheng Lin

Mei Gao

Hong Meng

Ruiming Xu

Jiachen Zi

Fengnian Han

Xuwei Ma

Zhulan Li

Shengyang Huang

Xiaona Fan

Zhenggang Yue

Li Sheng

Chenggen Zhu

Tiejun Zhang

The present invention provides N-substituted adenosine derivatives and N-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia. 

[object Object]

Provided is a pharmaceutical composition useful for prevention and/or treatment of diseases caused by bacteria, wherein the pharmaceutical composition comprising a honeysuckle extract containing iridoid compounds and an antibiotic. Also provided is a pharmaceutical kit comprising the honeysuckle extract containing the iridoid compounds and the antibiotics which are separately placed. The honeysuckle extract is used in combination with the antibiotics, the responsiveness of multi-drug resistant bacteria to antibiotics is improved, a clinical application prospect is presented, especially the current status of the refractory bacterial infection diseases caused by the pathogenic bacteria resistant to the antibiotics can be improved. Also provided is a use of the pharmaceutical composition and pharmaceutical kit in the preparation of drugs for prevention and/or treatment a diseases caused by bacteria. In addition, also provided is a use of the honeysuckle extract in the preparation of drugs for reversing bacterial resistance.

Pharmaceutical composition containing honeysuckle extract and antibiotics, pharmaceutical kit, and use of honeysuckle extract for preparation of drug

The use of extract form Wangla ((L) Hartm. Var.(Willd.) Richter), succinate derivative esters, and a derivative and pharmaceutical acceptable salts thereof, for the manufacture of a pharmaceutical preparation for the treatment of dementia, particularly for the treatment of Alzheimer' disease and Vascular dementia. Through Animal experiment, it has been demonstrated that, succinate derivative esters can improve learning and memory ability in dementia rats induced by scopolamine and cyclohexenyl imine; improve learning and memory ability in dementia rats induced by &#x3b2;-amyloid; improve learning and memory ability in dementia rats induced by permanent ligation of bilateral carotid; and improve memory ability of normal animals. It has the advantage of high activity, low toxicity and no inhibition to cholinesterase.

Use of derivatives of succinate esters for the treatment of dementia

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Beijing, China

Jiangong Shi