Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd.

Tyco Electronics Technology (sip) Co. Ltd.

Te Connectivity Corporation

Jianghua Zhu

Dongfang Shi

Xi Cheng

Changjin Fu

Jie Gu

Weiping Zhao

Pengfei Li

Yan Yang

Jie Wen

Siqi Chen

He Zhou

Fan Wu

Disclosed are a class of URAT1 inhibitor compounds and the use of such compounds. These compounds are compounds represented by the structure of formula (I) or pharmaceutically acceptable salts thereof. Experiments show that the compounds provided by the present invention have a very good inhibitory effect on hURAT1-transported uric acid in HEK293 transfected cells, and show that such compounds have a good potential for application in the treatment of hyperuricemia or gout.

URAT1 inhibitor and use thereof

The present invention belongs to the field of medicinal chemistry. Specifically disclosed is a class of URAT1 inhibitors for promoting uric acid excretion, which are compounds as represented by the structure of formula (I) or pharmaceutically acceptable salts thereof. Experiments show that the compounds provided by the present invention have a very good inhibitory effect on the transport of uric acid by hURAT1 in HEK293 transfected cells, and that such compounds have a good application prospect in the treatment of hyperuricemia or gout. 

URAT1 inhibitor for promoting uric acid excretion

The invention discloses a class of compounds for treating or preventing hyperuricemia or gout, which is a compound shown in general formula (I) or a pharmaceutically acceptable salt. These compounds and their pharmaceutically acceptable salts in the invention are useful for the promotion of uric acid excretion to treat or prevent hyperuricemia or gout.

Compound for treating or preventing hyperuricemia or gout

The invention discloses a connector, a connector, a matched connector, a matched connector and a connecting assembly. The connecting assembly includes the connector and the matched connector. A terminal fixing portion of the connector is provided with terminal accommodating cavities for accommodating connecting terminals. Separators for separating adjacent connecting terminals are disposed as protruding between the terminal accommodating cavities. The matched connector comprises insertion holes and isolating slots provided on a female end seat. The separators are inserted into the isolating slots. One end of the connecting terminal is disposed on the body of the connector, and the other end is held within the insertion hole and is connectable with a terminal connecting piece of the matched connector. The invention prevents connecting terminals from interfering with each other to provide a higher secure connection performance, while maintaining smaller spacing therebetween.

Connector, matched connector and connecting assembly

It discloses compounds for the treatment and prevention of breast cancer, which are specifically 2-phenyl benzoselenazole compounds, pharmaceutically acceptable salts thereof and prodrugs thereof. The present invention further discloses pharmaceutical compositions containing the compounds and applications of the compounds in preparing medicines for the treatment and prevention of breast cancer in mammals. The compounds of the present invention can effectively inhibit or reduce the growth or proliferation of breast cancer cells in mammals, with no inhibition effect on the growth of part of the tested cell lines except for the breast cancer cell lines, and are highly selective.

Compounds for the treatment or prevention of breast cancer

A connector is provided and includes a housing and a terminal position assurance article. The housing has a body and a terminal receiving portion extending rearward from the body. The terminal position assurance article is wholly received into a rear end of the housing and corresponds with the terminal receiving portion.

Growing community of inventors

Zhenjiang, China

Jianghua Zhu