British Columbia Cancer Agency Branch

Versitech, Inc.

Jianghong An

Steven J Jones

Allan Sik-Yin Lau

Lit Man Poon

Steven J M Jones

Oleksandr Yakovenko

Silvia Thoene

Pierre Yulmin Cheung

Hing-Yee Law

Chun-Wai Davy Lee

Hing Yee Law

Chun Wai Davy Lee

Chun Wai Lee

Steven Jm Jones

Methods of 'reprogramming' epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset the effects of aberrant writer activity (for example, loss of function or overactivity) that can contribute to certain diseases states, such as cancer. The use of the reprogramming compounds identified by these methods in the treatment of such disease states is also provided. Exemplary mark readers that can be targeted by these methods include BPTF and CBX2.

Reprogramming effector protein interactions to correct epigenetic defects in cancer

Carbamimidothioic acid esters of formula (I) and 2-nitro-N-[4-(pyridin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide are used for the treatment of influenza, and for the inhibition of a viral RNA-dependent RNA polymerase. Formulae (I), (II).

Anti-viral carbamimidothioic acid esters

The present invention provides pyrimidinyl compounds of formula (I) and pharmaceutically acceptable salts thereof. These compounds may be used for the inhibition of influenza. In particular, the compounds of the invention may be used for the treatment or prophylaxis of influenza A, most particularly H1N1 or H5N1 influenza. The compounds of the invention can also be used for the treatment or prophylaxis of a disease caused by, an orthomyxovirus, a paramyxovirus, a parainfluenza virus, mumps virus, Newcastle disease virus, fowl plague virus or Sendai virus. 

Anti-influenza compounds

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Vancouver, Canada

Jianghong An