Fluidigm Corporation

University of California

California Institute of Technology

Siemens Medical Solutions Usa, Inc.

Jiang Huang

Marc Alexander Unger

Emerson Cheung Quan

Hou-Pu Chou

Shoujun Xiao

Stephen R Quake

James R Heath

Hartmuth C Kolb

Arkadij M Elizarov

Hsian-Rong Tseng

Antoine Daridon

Michael E Phelps

Paul Wyatt

Chung-cheng Lee

Guodong Sui

Federico Goodsaid

New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

Microfluidic chemical reaction circuits

An M.times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.

Microfluidic devices and methods of using same

Thermal reaction device and method for using the same

An M&#xd7;N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.

The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between an intrinsic functional group that is present in the polymer and the functional group of the surface modifying compound. By using a polymer having an intrinsic functional group, a separate surface activation step is avoided.

Polymer surface modification

The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same. Preferably, the chromatography column comprises an OTLC, PCLC, or combinations thereof.

Microfluidic chromatography

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San Jose, CA, United States of America

Jiang Huang