Genentech, Inc.

F. Hoffmann-la Roche Ag

Jianfeng Xin

Steven Huy Do

Sushant Malhotra

Jack Alexander Terrett

Peter Scott Dragovich

Thomas Pillow

Lewis J Gazzard

Steven T Staben

Nicole Blaquiere

Binqing Wei

This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.

Fused ring compounds

The present disclosure relates to bifunctional compounds, which can be used as modulators of targeted ubiquitination. In particular, the present disclosure is directed to compounds which contain on one end a VHL ligand moiety, which binds to the VHL E3 ubiquitin ligase, and on the other end a moiety that binds a target protein such that degradation of the target protein/polypeptide is effectuated. Also disclosed are VHL ligands.

(4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof

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Beijing, China

Jianfeng Xin