Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Medshine Discovery Inc.

Jianfeng Mou

Haiying He

Songliang Wu

Shuhui Chen

Fengying Guo

Chuan Wang

Jian Li

Zhi Luo

Jie Li

Minggao Zeng

Guoqing Li

A compound represented by formula (I), a pharmaceutically acceptable salt or tautomer thereof, and an application of the compound as a caspase inhibitor. 

Bicyclic compound as a caspase inhibitor

Disclosed herein a crystal structure of a caspase inhibitor, and more specifically a crystal structure of an (S)-3-((S)-2-(5-(2-chlorophenyl)isoxazole-3-formylamide)proponamide)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)valeric acid, a preparation method therefor, a crystal polymer, a pharmaceutical composition and uses thereof. The compound A of formula (I) disclosed herein exhibits high crystal structure stability, low hygroscopicity, and advantageously shows physical properties, safety and metabolic stability while having relatively high pharmaceutical value.

Crystal of a caspase inhibitor

Disclosed are a class of compounds as a caspase inhibitor, and in particular the compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compound in treating caspase-related diseases. 

Caspase inhibitor and pharmaceutical composition, use and therapeutic method thereof

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Nanjing, China

Jianfeng Mou