University of Pittsburgh

Jianfei Jiang

Joel S Greenberger

Michael Wayne Epperly

Valerian Kagan

Peter Wipf

John S Lazo

Peter McDonald

Natalia A Belikova

Joshua Pierce

Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate apoptosis. The compounds comprise glyburide or other sulfonylurea hypoglycemic compounds or potassium channel inhibitors.

Radioprotective agents

Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

Use of targeted nitroxide agents in mitigating or treating radiation injury

Growing community of inventors

Pittsburgh, PA, United States of America

Jianfei Jiang