Cytokinetics, Inc.

Smithkline Beecham Corporation

Jianchao Wang

Bradley Paul Morgan

Gustave Bergnes

Luke W Ashcraft

David John Morgans, Jr

Xiangping Qian

Steven David Knight

Dashyant Dhanak

Kevin J Duffy

Bing Yao

Nicholas D Adams

Cynthia A Parrish

Duke Fitch

Rosanna Tedesco

Han-Jie Zhou

Andrew I McDonald

Jennifer Kuo Chen Huang

Scott E Collibee

Zhe Yang

Brian M Stoltz

Alex R Muci

Jeff Gardina

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.

Imidazole-benzamide anti-cancer agents

Imidazopyridinyl benzamide mitotic kinesin inhibitors

Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.

Certain chemical entities, compositions, and methods

Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders. 

Imidazoyl-benzamide anti-cancer agents

Imidazopyridinyl-benzamide anti-cancer agents

Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders. 

Certain 3,5-dibenzoyl-4-phenyl-piperidine compounds and salts thereof are provided herein. The compounds and salts may be useful in causing mitotic arrest and cell death. Also provided herein are certain pharmaceutical compositions comprising 3,5-dibenzoyl-4-phenyl-piperidine compounds or salts thereof and certain methods of use thereof.

3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds

Growing community of inventors

South San Francisco, CA, United States of America

Jianchao Wang