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Nanjing Sen Nan Biotechnology Research Co., Ltd.

Jianbao Han

Bo Liu

A peptide nucleic acid of subgroup J avian leukosis virus and uses of the same are provided. The sequence of the peptide nucleic acid is one or more selected from the following sequences: sequence 1: 5'AGACUAAGGCAAAAAUCUGUU-3&#x2032;; sequence 2: 5&#x2032;-ACGACUUAUUGAAAAACUCUC-3&#x2032;; sequence 3: 5&#x2032;-UAUAACCGUCUGUAGUUGGAC-3&#x2032;; sequence 4: 5&#x2032;-ACAUAUUUGAUUAUCUCUCCU-3&#x2032;. The peptide nucleic acid, disclosed in the present invention, can specifically and directly inhibit PRRSV replication, has good antiviral effect and no drug residues, without any toxic side effect and drug resistance.

Peptide nucleic acid of subgroup J avian leukosis virus and uses thereof

The present invention discloses a peptide nucleic acid for porcine reproductive and respiratory syndrome virus (PRRSV) and use thereof. The peptide nucleic acid of the present invention is selected from any one or more from the peptide nucleic acids having a) a nucleic acid sequence of Sequence 1 as shown in the Sequencing List; b) a nucleic acid sequence of Sequence 2 as shown in the Sequencing List; c) a nucleic acid sequence of Sequence 3 as shown in the Sequencing List; and d) a nucleic acid sequence of Sequence 3 as shown in the Sequencing List. The peptide nucleic acid of the present invention has no toxic side effect and no resistance, is able to specifically directly inhibit the replication of PRRSV, has a good anti-viral effect, and suffers no food safety problems including drug residue and others.

Peptide nucleic acid of porcine reproductive and respiratory syndrome virus and uses thereof

Disclosed are an anti-influenza nucleic acid, peptide nucleic acid and preparations thereof. The nucleic acid of the invention consists of any one or several of SEQ ID NOs: 1-12, and any one or several of SEQ ID NOs: 13-24. The peptide nucleic acid of the invention consists of any one or several of SEQ ID NOs: 25-36, and any one or several of SEQ ID NOs: 37-48. The peptide nucleic acid preparation of the invention has effective ingredients of said peptide nucleic acids. The anti-influenza peptide nucleic acid of the invention is of high bioavailability and stable physical and chemical properties with no toxic or side effect and no drug tolerance. With low cost, the drugs can inhibit influenza virus replication and have good anti-virus effect.

Anti-influenza nucleic acid, peptide nucleic acid and preparations thereof

An anti-WSSV and/or TSV nucleic acid drug, the active ingredients of which are five nucleic acids whose nucleotide sequences are sequence 1, sequence 2, sequence 3, sequence 4 and sequence 5 in the sequence list, respectively. The nucleic acid drug of the present invention has no toxic or side effect or drug tolerance, and can directly kill WSSV and/or TSV with fine antiviral effect and no drug residues.

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Nanjing, China

Jianbao Han