The General Hospital Corporation

Jian Yang

Chongzhao Ran

Anna Moore

Anna V Moore

Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.

Half-curcuminoids as amyloid-β PET imaging agents

Half-curcuminoids as amyloid-beta pet imaging agents

Provided herein are curcumin analogues that are able to interact with amyloid beta (A&#x3b2;) and to attenuate the copper-induced crosslinking of A&#x3b2;. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.

Growing community of inventors

Boston, MA, United States of America

Jian Yang