Fmc Corporation

Jian-Xin Li

Marina Yakovleva

Yuan Gao

B Troy Dover

Thomas A Ruszkay

Prakash Thyaga Palepu

Yangxing Li

Juergen Siepmann

Brian Fitch

Brian A C Carlin

Brian Carlin

Florence Siepmann

Thomas Ruszkay

Anthony Christopher Carlin

Brian AC Carlin

Troy B Dover

A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.

Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations

A composition comprising: (i) at least one latex or pseudolatex water insoluble film former, (ii) at least one permeation enhancing agent and, optionally, (iii) one or more plasticizers. The present invention is also directed to substrates coated with the composition of the invention, films made from the composition and methods for making and using such compositions, coated substrates and films.

Latex or pseudolatex compositions, coatings and coating processes

An aqueous polymer coating composition containing at least one latex or pseudolatex is coated on a substrate in a high humidity coating process followed by heat treatment of the coated substrate above the film forming temperature of the coating at low humidity. The coated substrate gives a stable reproducible dissolution profile substantially insensitive to temperature or humidity conditions upon storage. The high humidity coating process is achieved by addition of water to the coating chamber through dilution of the coating formulation or humidification of inlet air. Contrary to the conventional low humidity coating process, residual water is retained in the coating layer of the coated substrates in the coating step. When the coated substrates are heat treated at a temperature greater than the minimum film forming temperature, the residual water in the coating layer will ensure adequate capillary force for the completion of film coalescence. High humidity heat treatment is not needed.

Coating process to produce controlled release coatings

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North Brunswick, NJ, United States of America

Jian-Xin Li