Chdi Foundation, Inc.

Knopp Biosciences, LLC

Imago Biosciences, Inc.

Knopp Neurosciences, Inc.

Jian-Xie Chen

John Michael McCall

Olga V Lapina

Prasad Raje

Rajendrakumar Reddy Gadikota

Celia Dominguez

Stephan D Parent

Arthur Glenn Romero

He Zhao

Travis Lee Houston

Cassandra Celatka

Leticia M Toledo-Sherman

Amy E Tapper

Elisabeth C A Brot

Xuemei Chen

Zhihua Li

Xiaoming Liao

Toni Chancellor

Geetha Banda

Vinod Khetarpal

Betina Biolatto

Charles H Montgomery

Provided in this disclosure are methods for the synthesis of substituted 2-arylcyclopropylamines and 2-heteroarylcyclopropylamines and related compounds. Also provided are methods for reduction of thioesters to aldehydes, and methods for reductive animation of cyclopropylamines.

Methods and processes for the preparation of KDM1A inhibitors

Forms of 6-(3-chloro-4-cyclopropoxyphenyl)pyrimidine-4-carboxylic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I and salts or co-crystals thereof.

Solid forms of a kynurenine-3-monooxygenase inhibitor

Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzothiazole diamines such as, for example, (6R)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzothiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzothiazole diamines are provided herein.

Synthesis of chirally purified substituted benzothiazole diamines

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Schenectady, NY, United States of America

Jian-Xie Chen