Ortho-Mcneil Pharmaceutical Corp.

Jian-Shen Qi

Andrew Lawrence Darrow

Patricia Andrade-Gordon

Cailin Chen

A novel human cDNA, termed PRSS11-L, was isolated which encodes a polypeptide that belongs to the S2/HtrA serine protease family. The PRSS11-L mRNA is widely expressed in several tissues throughout the body by multi-tissue Northern blotting. The full-length PRSS11-L cDNA, was cloned, expressed and purified. Proteolytic activity was demonstrated using the protein substrate casein. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.

Human PRSS11-like S2 serine protease and uses thereof

A novel human nucleic acid and polypeptide, termed PRSS11-L, are disclosed. PRSS11-L, which is observed in tissues throughout the body, can be used in methods of detection, gene therapy, and screening.

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Branchburg, NJ, United States of America

Jian-Shen Qi