The Walter and Eliza Hall Institute of Medical Research

Zenyth Operations Pty. Ltd.

Jian-Guo Zhang

Douglas James Hilton

Nicos Anthony Nicola

Tracy Ann Willson

Warren S Alexander

Alison Farley

Manuel Baca

Richard John Simpson

Andrew Donald Nash

Donald Metcalf

Tetsuo Kojima

Louis Jerry Fabri

Sandra Elaine Nicholson

Yasufumi Kikuchi

Mireille Hanna Lahoud

Irina Caminschi

David Ching Siang Huang

Ken Shortman

Mark Dexter Wright

Masatsugu Maeda

Steven Rakar

Mark Francis Van Delft

The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.

Haemopoietin receptor and genetic sequence encoding same

The present invention relates generally to amino acid sequences obtainable from SOCS proteins and which are capable of interacting with intracellular molecules. The present invention further relates to nucleic acid molecules encoding said amino acid sequences. The amino acid sequences and the nucleic acid molecules encoding same of the present invention are useful in modulating degradation of proteinaceous molecules such as but not limited to SOCS proteins and proteinaceous molecules associated therewith. The present invention provides a mechanism for modulating cytokine or cytokine-like molecule signalling by modulating the degradation of activated signal transduction molecules or their negative regulators, i.e. the SOCS proteins.

Screening methods using SOCS box-containing peptides

Growing community of inventors

North Melbourne, Australia

Jian-Guo Zhang