The Walter and Eliza Hall Institute of Medical Research

Amrad Operations Pty Ltd

Jian Guo Zhang

Douglas James Hilton

Nicos Anthony Nicola

Manuel Baca

Andrew Donald Nash

Donald Metcalf

Louis Jerry Fabri

Tracy Ann Willson

Sandra Elaine Nicholson

The present invention relates generally to a method for regulating cytokine signaling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signaling (SOCS) interaction in controlling cytokine signaling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signaling. Control of cytokine signaling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.

Methods of regulating cytokine signalling

The present invention relates generally to a novel haemopoietin receptor or components or part thereof and to genetic sequences encoding same. The receptor molecules and their components and/or parts and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.

Haemopoietin receptor and genetic sequences encoding same

Growing community of inventors

North Melbourne, Australia

Jian Guo Zhang