Shanghai Biomodel Organism Science & Technology Co., Ltd.

Shanghai Research Center for Model Organisms

Shanghai Centre of Research & Development of New Drugs

Shanghai Newsummit Biopharma Co., Ltd

Shanghai Yizhong Biotechnology Co., Ltd

Jian Fei

Jun Li

Jiang Li

Yi Lu

Xin Gao

Qingcheng Wang

Jiuru Sun

Youshang Zhang

Yangbin Huang

Ruling Shen

Zhugang Wang

Dafu Cui

The invention discloses a kit which comprises a formulation containing artemisinin or the derivatives thereof, a formulation containing ribonuclease, and a specification.

Combined use of ribonuclease and artemisinin

The present invention provides a novel fusion protein suitable for high expression and the production method thereof. The structure of the fusion protein is A-C1-K-(B-C2-K)n-D, wherein A is the upstream peptide; each of C1 and C2 is independently short peptides having 20-40 amino acids in length and containing no Lys in sequence; K is Lys; B is a linker; D is a downstream peptide; n is an integer of 3-30. The fusion protein is expressed with high efficiency and stability in host cells. The purification and enzymatic cleavage technology of the expression product is simple, which is able to produce a short peptide with high efficiency, and has very high value of industrialization.

Fusion protein suitable for high efficiency expression and the production method thereof

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Shanghai, China

Jian Fei