Beijing Junke Huayuan Med Tech Co., Ltd.

Taizhou Huayuan Medicinal Tech Co. Ltd.

Jiajun Yang

Bohua Zhong

Jianming Wang

The present invention provides compounds as represented by structural formula (I). In formula (I), R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, and R14 are separately H or deuterium (D) independently. Moreover, at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, and R14 must be D. Also provided is use of any of the compounds or its pharmaceutical composition in the preparation of a drug for treating an anxiety.

Anxiolytic deuterated compound and medical use thereof

The present invention relates to a compound represented by formula I and a non-toxic pharmaceutically acceptable salt thereof. In formula (I), R1 is H, CHor deuterated methyl (CD); R2 is CHor CHCH; R3, R4 and R5 are each independently H or deuterium (D); when R1 is H or CH, at least one of R3, R4 and R5 is D. 

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Jiangsu, China

Jiajun Yang