Mayo Foundation for Medical Education and Research

Jia Yu

Liewei Wang

Matthew P Goetz

Judy C Boughey

Ping Chen

William S Brimijoin

Liyi Geng

Yang Gao

Bo Qin

This document provides methods and materials for using butyrylcholinesterases (BChE) to treat cancer (e.g., triple negative breast cancer or prostate cancer). For example, methods and materials for using nucleic acid vectors (e.g., viral vectors) to express BChE polypeptides under conditions that reduce the number of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) and/or reduce the growth rate of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) are provided.

Methods and materials for using butyrylcholinesterases to treat cancer

This document provides methods and materials involved in treating cancer. For example, methods and materials for using an inhibitor of USP7 polypeptide to increase the sensitivity of cancer cells (e.g., CD340cancer cells such as HER2cancer cells) to treatment with an inhibitor of a CD340 polypeptide (e.g., an inhibitor of a HER2 polypeptide) are provided. Methods and materials for using USP7 polypeptide inhibitors in combination with CD340 polypeptide inhibitors to treat cancer (e.g., HER2breast cancer that was refractory to trastuzumab alone treatment) are provided.

Methods and materials for treating cancer

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Rochester, MN, United States of America

Jia Yu