Peking University

Lunan Pharmaceutical Group Corporation

Jia Ye

Xin Wang

Runtao Li

Zemei Ge

Qi Sun

Ding Wang

Jingchun Yao

Tieming Cheng

Guimin Zhang

Caiqin Yue

Changling Li

Xiaolei Du

Yingying Liang

Guifang Zhao

Disclosed are a compound represented by the general Formula (I), or a stereisomer, tautomer, derivative, prodrug or pharmaceutically acceptable salt thereof, and a method for preparing the compound and use of the compound in manufacture of a medicament for treating a neuropathic pain and/or neuropathic pain syndrome or a medicament for combating an inflammation:

Anti-pain compound and preparation method thereof

Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives, prodrugs or pharmaceutically acceptable salts, and their preparation methods or uses for the manufacture of a medicament of analgesics. In which Ris selected from H, substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl; A is bond, or saturated or unsaturated straight-chain or branched-chain hydrocarbon radical; R, Rare each independently hydrogen or methyl, which linked with any position of spirocyclo-structure; n and m are each independently integer between 0-2, do not represent 0 at the same time; B and D are each independently C-Cstraight-chain or branched-chain alkylene; Y is selected from &#x2014;CHR&#x2014;, O, S, &#x2014;S(O)&#x2014;, &#x2014;SO&#x2014;, &#x2014;NR&#x2014; and substituted or unsubstituted phenylene, in which Rrepresents H, C-Csaturated or unsaturated alkyl, methyl or ethyl substituted by substituted or unsubstituted aryl or heteroaryl; and Xis pharmaceutical acceptable organic or inorganic anion. These compounds can be used as muscarine receptor (M-receptor) and/or nicotine acetylcholine receptor (N-receptor) agonist or antagonist. These compounds have good analgesic effect without side effect such as addiction. 

Quaternary ammonium salt compounds of spirocyclopiperazines, preparation methods and uses thereof

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Jia Ye