The Scripps Research Institute

Hesperix Sa

Zebra Biologies, Inc.

Jia Xie

Richard A Lerner

Dmitry Dmitrievich Genkin

Hongkai Zhang

Alexander Gabibovich Gabibov

Alexey Vyacheslavovich Stepanov

Alexey Anatolievich Belogurov

Philip E Dawson

Ronald M Lindsay

Patricia McDonald

Emmanuel Sturchler

Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.

Articles and methods directed to personalized therapy of cancer

The invention provides TrkB agonist antibodies or antigen-binding fragments that specifically enhance TrkB signaling activities. The invention also provides therapeutic methods of using such antibodies for promoting survival and regeneration of retinal ganglion cells, and for treating or preventing subjects suffering from or at risk of developing various neurodegenerative conditions such as glaucoma.

TrkB agonist antibodies and methods for treating an ocular degenerative disorder characterized by degeneration of retinal ganglion cells (RGCs)

The invention provides combinatorial peptide or polypeptide libraries that can become membrane tethered once expressed in cells. The invention additionally provides methods for selecting peptide modulators (e.g., agonists) of GPCRs from the combinatorial libraries of the invention. The invention also provides novel GPCR polypeptide modulators, e.g., biased polypeptide agonists of the glucagon-like peptide 1 receptor (GLP-1R). The invention further provides methods of promoting insulin sensitivity, lowering blood glucose, and reducing body weight as well as methods for treating various diseases such as diabetes and obesity.

Methods and compositions related to GPCR agonist polypeptides

The invention provides methods for identifying binding partners (e.g., peptide ligands) that binds to a target protein (e.g., a cellular receptor). The methods entail co-localized expression of the target protein and candidate binding partners, and selection of binding partners based on their proximity in the plasma membrane.

Proximity based methods for selection of binding partners

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San Diego, CA, United States of America

Jia Xie