Chinese Academy of Sciences

Zhejiang University

Other

Huawei Technologies Co., Limited

International Business Machines Corporation

Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.

Zibo Biopolar Changsheng Pharmaceutical Co. Ltd.

Silver Rocket Data Technology (shanghai) Co., Ltd

Hoffmann-la Roche Inc.

Sandisk Technologies Inc.

Volvo Car Corporation

Shenzhen Yinwang Intelligent Technologies Co., Ltd.

East China University of Science and Technology

Van Andel Research Institute

Cisen Pharmaceutical Co., Ltd.

Jia Tao Li

Yubo Zhou

Jingya Li

Hualiang Jiang

Fajun Nan

Anhui Gao

Mingbo Su

Jiang Wang

Hong Tao Liu

Kaixian Chen

Jian Li

Zhijian Lu

Xibin Liao

Yongzhou Hu

Yi Yuan

Tao Liu

Xiaoliang Pan

Jian Ding

Yangming Zhang

Xiaomin Luo

Xiaowu Dong

Xiaobei Hu

Qing Yan

Mei Zhang

Yi Zang

Wei Zhang

Wei Zhu

Jun Wei Zhang

Jie Liu

Meiyu Geng

Lei Xu

Bo Yang

Xin Xie

Lingzhi Mao

Qiaojun He

Peipei Wang

Weijuan Kan

Shuni Wang

Zhifu Xie

Chunpu Li

Dandan Sun

Qian Tan

Pinrao Song

Lexian Tong

Chaojun Gong

Lifei Dang

Matthew E Broomhall

Li Chen

Gang Liu

Tao Li

Lei Shi

Mengmeng Zhang

Chin-Tien Chiu

Qi Rong Wang

Yi Chen

Yang Zhang

Hua Fang Tan

Lichun Feng

Hui Chen

Jun Ma

Yu Cheng

Dan Li

Fei Chen

Zhong Lu

Jingkang Shen

Xiaohua Chen

Fabrizio Nascimento Caldas

Christopher R Dotson

Jing Ai

Mengwei Huang

Kai Yan

Honglin Li

Zehong Miao

Xia Peng

Jianhui Yao

Yufang Xu

Zhenjiang Zhao

Xueming Peng

Weihua Shan

Linghua Meng

Jingjing Shi

Min Gu

Bing Xiong

Yihua Chen

Cheng Zhao

Lixin Gao

Li Kong

Yinchun Ji

Shengbin Zhou

Yang Dong

Qinjie Weng

Shiliang Li

Wenhu Zhan

Hong Fu Wei

Yujie Wang

Yi Wei

Huajie Zhang

Danqi Chen

Haibo Liang

Qi Chen

Provided by the present disclosure are an amino quinazolinone and amino isoquinolone derivatives. It is verified by numerous experiments that the compounds provided by the present disclosure have good inhibiting effects on PI3Kα and PI3Kγ, most of the compounds have prominent inhibiting effect on PI3Kα, and show strong growth inhibiting effect on PIK3CA mutant tumor cells such as human breast cancer cell strain (MCF7). Therefore, the amino quinazolinone and amino isoquinolone derivatives according to the present disclosure can be applied in the preparation of anti-tumor and anti-inflammatory medicines, and can be used as PI3Kα inhibitors in the preparation of medicines for treatment of human or animal cell proliferation related tumors, the medicines comprising the derivatives any one or more of pharmaceutically acceptable salts and solvates thereof as well as pharmaceutically acceptable carriers. Formulas a and b are shown as below:

Aminoquinazolinone and aminoisoquinolinone derivatives and application thereof

A map building apparatus includes a memory storing instructions, and a processor executing the instructions to obtain a plurality of frames of images that carry image information of a target environment, obtain a motion parameter of the image capture component at a capture location of each frame of the plurality of frames of images, obtain a relative displacement between capture locations of each two frames of images based on the motion parameter of the image capture component, obtain, based on the plurality of frames of images and the relative displacement, a map layer including feature points in the plurality of frames of images, and send the map layer and the relative displacement to a server. The plurality of frames of images are captured by an image capture component. The motion parameter indicates a motion status of the image capture component. The map layer is useable to build a map.

Map building method, apparatus, and system, and storage medium

An FXR small molecule agonist and a preparation method therefor and a use thereof, having a structure as shown in formula (I). The compound represented by formula (I) has FXR agonistic activity and is capable of preparing drugs for treatment of FXR-related diseases.

FXR small molecule agonist and preparation method therefor and use thereof

A semiconductor wafer includes semiconductor dies and laser grooves formed in the scribe lines along the long edges of the semiconductor dies. A laser groove extends between the long edges of two adjacent semiconductor dies to encompass the corners of the two adjacent semiconductor dies. When diced, the resulting semiconductor dies have portions of the corners removed.

Semiconductor wafer and semiconductor dies formed therefrom including grooves along long edges of the semiconductor dies

Bruton's tyrosine kinase (Btk) inhibitors have the following Formula (I):

Bruton's tyrosine kinase inhibitors

The present invention relates to the fields of medicinal chemistry and pharmacotherapy, and specifically relates to the chemical compound of formula (I), and its racemate, R-isomer, S-isomer, pharmaceutically acceptable salt, and mixtures thereof, as well as its method for preparation, a pharmaceutical composition containing said chemical compound, and use as a lysine-specific demethylase 1 (LSD 1) inhibitor. The cyclopropylamine chemical compound to which the present invention relates may be used in the treatment of cancer.

Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof

Disclosed is use of a thieno[3,2-d]pyrimidin-4-one compound represented by general formula (I). Definition of each substituent is as stated in the description and claims, and the compound is used for preparing medicines for treating and/or preventing liver fibrosis and related diseases or preparing a DPP-4 inhibitor, or is used as a DPP-4 inhibitor.

Pharmaceutical use of thiophene [3,2-d] pyrimidine-4-ketone compound

The present disclosure relates to a fused ring pyrimidine amino compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically disclosed in the present disclosure are the compound shown in formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof. The fused ring pyrimidine amino compound of the present application has good inhibitory activity against DDRs, particularly DDR2, and has a good therapeutic effect on tumors and fibrotic diseases, especially pulmonary inflammation and pulmonary fibrosis. Also disclosed in the present disclosure are a preparation method for the compound shown in formula I, and a use thereof. 

Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof

Embodiments of the present invention relate to methods, systems, and computer program products for file management in a distributed file cache system. In some embodiments, a method is disclosed. According to the method, responsive to determining that at least one client node is obtaining a file of a first version stored at a storage node, one or more processors generate contact information indicating that the file of the first version is accessible from the storage node and the at least one client node and recorded the contact information into a distributed hash table. The storage node and the at least one client node are included in a plurality of nodes associated with the distributed hash table. Further, one or more processors generate first version information indicating that the file is of the first version and record the first version information into a blockchain associated with the plurality of nodes.

Distributed file cache

The present invention provides a 2-polysubstituted aromatic ring-pyrimidine derivative and an optical isomer thereof, or a pharmaceutically acceptable salt or solvate thereof, the compound, and an optical isomer thereof or a pharmaceutically thereof acceptable salts or solvates can be used in the preparation of anti-tumor drugs. The invention designs and synthesizes a series of novel small molecule Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained by structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess potent anticancer activity, Chk1 kinase inhibitory activity, and are promising Chk1 inhibitors, and can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal. The 2-polysubstituted aromatic ring-pyrimidine derivatives provided by the present invention has the structure of the formula I: 

2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof

Bruton's tyrosine kinase (Btk) inhibitors have the following Formula (I): 

A system may be disclosed in the present disclosure, comprising: an interface service unit configured to perform at least one of sending data to or receiving data from one or more users via a user interface; and a transmission unit including: a blockchain adaptor configured to transmit data to a plurality of different types of blockchains, via a blockchain interface, according to data format and communication mode requirements of each of the plurality of different types of blockchains and a transmission controller configured to trigger a smart contract running on a blockchain of the plurality different types of blockchains via the blockchain interface, and control a data transmission under instructions from the smart contract, wherein the data transmission is based on data received from the user interface.

Data service system

A data transmission platform for data transmission using a blockchain is configured to receives ciphertext data from a data provider, wherein the ciphertext data include transmitted data authenticated by the data transmission platform and encrypted by the data provider; identifies a target data requestor; creates a smart contract according to a data transmission requirement of the target data requestor; uploads the smart contract to a blockchain; sends a data transmission request to the data provider; re-encrypts the ciphertext data to obtain re-encrypted data using a re-encryption key generated by the data provider; triggers the smart contract to send the data transmission demand of the data requestor to the data provider; and notifies the data requester to extract the decrypted data and perform decryption to obtain the transmitted data.

Data transmission method, system and platform using blockchain, and storage medium

A power battery cooling system of an electric vehicle, including: a cooling circuit configured for cooling a power battery of the electric vehicle; a solar sunroof; and a sunroof control unit configured for controlling the operation of the cooling circuit and the electric energy output of the solar sunroof; wherein the sunroof control unit is configured to start a power battery cooling operation based on the solar sunroof in the condition that the power battery is not in a high voltage output state and the temperature of the power battery is higher than a temperature threshold, the power battery cooling operation including: controlling the solar sunroof to output electric energy to the cooling circuit so that the cooling circuit performs the cooling of the power battery using the electric energy from the solar sunroof.

Power battery cooling system and method based on solar sunroof

A resource scheduling method and a related resource scheduling apparatus to improve data input/output (I/O) efficiency, where the method includes determining a current task queue, where the current task queue includes a plurality of to-be-executed application tasks, determining, for data blocks on a disk to be accessed by the application tasks, a quantity of times that each data block is to be accessed by the application tasks, determining a hotspot data block according to the quantity of times that each data block is to be accessed by the application tasks, and sending a move-in instruction to a local node of the hotspot data block, where the move-in instruction instructs to move the hotspot data block into a memory such that the hotspot data block can be accessed in the memory.

Resource scheduling method and related apparatus

Growing community of inventors

Beijing, China

Jia Tao Li