National Yang Ming Chiao Tung University

Jia-Je Li

Hsin-Ell Wang

Shun-Fu Chang

Keng-Li Lan

Cheng Allen Chang

C Allen Chang

Roy Chen-Chih Wu

Pei-Chia Chan

The present invention provides a targeted prodrug enzyme fusion carrier comprising a targeted molecule and a prodrug enzyme. The targeted prodrug enzyme fusion carrier can effectively identify and bind to tumor cells and tumor-induced tumor angiogenesis. The targeted prodrug enzyme fusion carrier also has a targeted prodrug enzyme fusion protein and a theranostic system utilizing the method of in vivo nuclear medicine for the clinical diagnosis and treatment of individual patients with tumors.

Targeted prodrug cytosine deaminase fusion carrier and application thereof

A dual targeting drug carrier is provided. The dual targeting drug carrier comprises a first targeting molecule and a second targeting molecule, wherein the targeting molecule comprises peptide, protein or antibody. The targeting molecule can bind to specific receptors, proteins, or glycoproteins to recognize the specific tumor cells, tissues, or organs. The dual targeting drug carriers are further conjugated with imaging agents, radioactive molecules (radiopharmaceuticals, isotopes, or chemotherapeutic drugs) or nanoparticles to form a conjugate.

Dual targeting drug carrier and application thereof

Growing community of inventors

Taipei, Taiwan

Jia-Je Li